Nathalie C. LAMBERT – PhD

Position: INSERM Researcher CRCN

EDUCATION

1993 – Master Degree, Paris VII University, France and training at SANOFI, Montpellier, France.
1997 – PhD in Biology, structure and function of osteoarticular tissues. Paris VII University, France
2005 – French university degree to supervise PhD students (HDR). Aix Marseille University, France.

ACADEMIC/ PROFESSIONAL APPOINTMENTS

1997-2000 – Post-doctorate, Immunogenetic department, Fred Hutchinson Cancer Research Center (FHCRC), Seattle USA
2000- 2003 – Research Associate, Immunogenetic department, FHCRC, Seattle USA
2004-2008 – Researcher (CR2) at the INSERM U639, Faculty of Medicine La Timone, Marseille
2008-present – Researcher (CR1) at the INSERM UMRs1097, Luminy, Marseille

ACHIEVEMENTS

Vice-president of the French Scleroderma Research Group (GFRS)

peer-reviewed publications

as last author

as corresponding author

book chapters

patents (one with license)

FIELDS OF INVESTIGATION

Predominance of women in rheumatic autoimmune diseases (systemic sclerosis, rheumatoid arthritis).

Fetal and maternal microchimerism (Mc) resulting from trans-placental exchanges during pregnancy. Role of Mc in pregnancy, transplantation (cord blood (link here) and autoimmune diseases.

Classical and non-classical human leukocyte antigens (HLA), feto-maternal HLA compatibility

X chromosome: X-linked genes, inactivation / expression, copy number variation (CNV)

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Email

nathalie.lambert@inserm.fr

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Phone

+33491828768

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Adress

INSERM UMRs 1097, Autoimmune Arthritis,

Parc Scientifique de Luminy, 163 Avenue de Luminy, 13288 Marseille, France.

TOP- 10 PEER-REVIEWED PUBLICATIONS

Lambert, N. C., Lo, Y. M., Erickson, T. D., Tylee, T. S., Guthrie, K. A., Furst, D. E., & Nelson, J. L. Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer. Blood. 2002 Oct 15;100(8):2845-51. PMID: 12351394

Lambert, N. C., Erickson, T. D., Yan, Z., Pang, J. M., Guthrie, K. A., Furst, D. E., & Nelson, J. L. Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: studies of healthy women and women with scleroderma. Arthritis Rheum. 2004 Mar;50(3):906-14. PMID: 15022334

Rak, J. M., Maestroni, L., Balandraud, N., Guis, S., Boudinet, H., Guzian, M. C., Yan, Z., Azzouz, D., Auger, I., Roudier, C., Martin, M., Didelot, R., Roudier, J., & Lambert, N. C. Transfer of the shared epitope through microchimerism in women with rheumatoid arthritis. Arthritis Rheum. 2009 Jan;60(1):73-80. doi: 10.1002/art.24224.PMID: 19117368

Rak, J. M., Pagni, P. P., Tiev, K., Allanore, Y., Farge, D., Harlé, J. R., Launay, D., Hachulla, E., Didelot, R., Cabane, J., Kahan, A., Martin, M., Granel, B., Roudier, J., & Lambert, N. C. Male microchimerism and HLA compatibility in French women with sclerodema: a different profile in limited and diffuse subset. Rheumatology (Oxford). 2009 Apr;48(4):363-6. doi: 10.1093/rheumatology/ken505. Epub 2009 Feb 10. PMID:19208687

de Bellefon, L. M., Heiman, P., Kanaan, S. B., Azzouz, D. F., Rak, J. M., Martin, M., Roudier, J., Roufosse, F., & Lambert, N. C. Cells from a vanished twin as a source of microchimerism 40 years later. Chimerism. 2010 Oct;1(2):56-60. doi: 10.4161/chim.1.2.14294. PMID: 21327048

Azzouz, D. F., Rak, J. M., Fajardy, I., Allanore, Y., Tiev, K. P., Farge-Bancel, D., Martin, M., Kanaan, S. B., Pagni, P. P., Hachulla, E., Harlé, J. R., Didelot, R., Granel, B., Cabane, J., Roudier, J., & Lambert, N. C. Comparing HLA shared epitopes in French Caucasian patients with scleroderma. PLoS One. 2012 ;7(5):e36870. doi: 10.1371/journal.pone.0036870. Epub 2012 May 15.PMID: 22615829

Azzouz, D. F., Martin, G. V., Arnoux, F., Balandraud, N., Martin, T., Dubucquoi, S., Hachulla, E., Farge-Bancel, D., Tiev, K., Cabane, J., Bardin, N., Chiche, L., Martin, M., Caillet, E. C., Kanaan, S. B., … Lambert, N. C. Anti-Ephrin Type-B Receptor 2 (EphB2) and Anti-Three Prime Histone mRNA EXonuclease 1 (THEX1) Autoantibodies in Scleroderma and Lupus. PLoS One. 2016 Sep 12;11(9):e0160283. doi:10.1371/journal.pone.0160283. eCollection 2016. PMID: 27617966

Nelson, J. L., & Lambert, N. C. Rheumatoid arthritis: Forward and reverse inheritance – the yin and the yang. Nat Rev Rheumatol. 2017 Jul;13(7):396-397. doi: 10.1038/nrrheum.2017.88. Epub 2017 Jun 8. No abstract available. PMID: 28592894

Lambert N. C. Nonendocrine mechanisms of sex bias in rheumatic diseases. Nat Rev Rheumatol. 2019 Nov;15(11):673-686. doi: 10.1038/s41584-019-0307-6. PMID: 31597952

Martin, G. V., Kanaan, S. B., Hemon, M. F., Azzouz, D. F., El Haddad, M., Balandraud, N., Mignon-Ravix, C., Picard, C., Arnoux, F., Martin, M., Roudier, J., Auger, I., & Lambert, N. C. Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis. Sci Rep. 2019 Sep 9;9(1):12880. doi:10.1038/s41598-019-49309-4. PMID: 31501466

Haddad, M. E., Karlmark, K. R., Donato, X. C., Martin, G. V., Bretelle, F., Lesavre, N., Cocallemen, J. F., Martin, M., Picard, C., Roudier, J., Desbriere, R., & Lambert, N. C. Factors predicting the presence of maternal cells in cord blood and associated changes in immune cell composition. Immunol. 2021, 12:651399.doi: 10.3389/fimmu.2021.651399 PMID: 33968049