Jean ROUDIER – MD and PhD

Position: Professor of Medicine, Head of INSERM UMRs1097

EDUCATION

1983 – Lyon II University, School of Medicine M.D.
1983 – Board certified Rheumatologist,
1989-1991 – Licensed physician in California,
1992 – Marseilles Luminy, School of Sciences, Ph.D.

ACADEMIC/ PROFESSIONAL APPOINTMENTS

1978-1984 – Internship and Residentship: Hospices civils de Lyon
1984-1986 – Assistant Professor of Medicine: Aix Marseille University
1986-1989 – Research Associate then Senior Research Associate: Scripps Clinic and Research Foundation, La Jolla, California, USA
1990-1991 – Assistant Professor of Medicine, UCSD School of Medicine, San Diego, California, USA,
1992-1997 – Adjunct Associate Professor of Medicine, UCSD School of Medicine, San Diego, California,USA,
1991- present – Professor of Medicine (Rheumatology) Aix Marseille University
1991- present – Head of « Autoimmune Arthritis » Laboratory, now INSERM UMRs1097

ACHIEVEMENTS

Arthritis Foundation Investigator Award 1990

FIELDS OF INVESTIGATION

I have been investigating how HLA-DR genes predispose to rheumatoid arthritis since 1984. We finally came up with the « hapten carrier » model, published in 2020. This model predicts that rheumatoid arthritis could be cured/prevented by PAD tolerization.

TOP- 10 PEER-REVIEWED PUBLICATIONS

Auger I, Balandraud N, Massy E, Hemon MF, Peen E, Arnoux F, Mariot C, Martin M, Lafforgue P, Busnel JM, Roudier J. Peptidylarginine Deiminase Autoimmunity and the Development of Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten-Carrier Model. Arthritis Rheumatol. 2020 Jun;72(6):903-911. doi: 10.1002/art.41189. Epub 2020 Apr 26. PMID: 31820586

Arnoux F, Mariot C, Peen E, Lambert N, Balandraud N, Roudier J, Auger I. Peptidyl arginyl deiminase immunization induces anti citrullinated protein antibodies in mice with particular MHC types. Proceedings of the National Academy of Sciences USA 2017 ;114:E10169-E10177. PMID: 29109281

Balandraud N, Picard C, Reviron D, Landais C, Toussirot E, Roudier J. HLA-DRB1 genotypes and the risk of developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis. PLoS ONE. 2013 8(5): e64108. doi:10.1371/journal.pone.0064108

Auger I, Martin M, Balandraud N, Roudier J. Rheumatoid arthritis specific autoantibodies to peptidyl arginyl deiminase type 4 inhibit citrullination of fibrinogen. Arthritis Rheum. 2010 Jan;62(1):126-31. doi: 10.1002/art.27230. PMID: 20039406.

Auger I, Balandraud N, Rak J, Lambert N, Martin M, Roudier J. New autoantigens in rheumatoid arthritis: screening 8268 protein arrays with RA patients’ sera. Annals of the Rheumatic Diseases, 2009 Apr;68(4):591-4. doi: 10.1136/ard.2008.096917. Epub 2008 Oct 28. PMID: 18957483.

Auger I, Sebbag M, Vincent C, Balandraud N, Guis S, Nogueira L Svensson B, Cantagrel A, Serre G, Roudier J. Influence of HLA-DR genes on the production of rheumatoid arthritis specific autoantibodies to citrullinated fibrinogen. Arthritis and Rheumatism 2005 Nov;52(11):3424-32. doi: 10.1002/art.21391. PMID: 16255019.

Auger I, Roudier J. A function for the QKRAA amino acid motif mediating binding of DnaJ to DnaK. Implications for the association of rheumatoid arthritis with HLA-DR4. Journal of Clinical Investigation 1997 Apr 15;99(8):1818-22. doi: 10.1172/JCI119348. PMID: 9109425; PMCID: PMC508005.

Auger I, Escola JM, Gorvel JP, Roudier J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70kD heat shock proteins. Nature Medicine 1996 Mar;2(3):306-10. doi: 10.1038/nm0396-306. PMID: 8612229.

Albani S, Tuckwell J, Esparza L, Carson D, Roudier J. The susceptibility sequence to Rheumatoid arthritis is a cross reactive B epitope shared by the E coli DnaJ heat shock protein and the HLA -DRB1*0401 molecule. Journal of Clinical Investigation 1992 Jan;89(1):327-31. doi: 10.1172/JCI115580. PMID: 1370300; PMCID: PMC442852.

Roudier J, Petersen J, Rhodes G, Luka J, Carson D A. Susceptibility to rheumatoid arthritis maps to a T cell epitope shared by the HLA Dw4 DR beta 1 chain and the Epstein Barr virus glycoprotein gp110. Proceedings of the National Academy of Sciences of the United States of America 1989 Jul;86(13):5104-8. doi: 10.1073/pnas.86.13.5104. PMID: 2472638; PMCID: PMC297565.