Isabelle AUGER – PhD

• 1994 – Master Degree,  Aix Marseille university, Marseille, France
• 1997 – PhD in Biology, Immunology, Aix Marseille university, Marseille, France
• 2005 –  French university degree to supervise PhD students (HDR). Immunology, Aix Marseille university, Marseille, France

• 1999 – INSERM Researcher CR2

• 1998-1999 – Post doctoral position, INSERM U463, Institut de Biologie, Nantes, France

• 1997 – Post doctoral position, INSERM U639, Marseille, France

Autoantibodies and rheumatoid arthritis (RA)

How Human Leukocyte Antigen (HLA)-DRB1 genes control the production of RA specific autoantibodies

New model to explain the emergence of anti-citrullinated protein autoantibodies in RA

Development of new immunotherapy to treat and prevent RA

Auger I, Balandraud N, Massy E, Hemon MF, Peen E, Arnoux Fanny, Mariot C, Martin M, Lafforgue P, Busnel JM, Roudier J. Peptidyl arginine deiminase autoimmunity and the development of ACPA in rheumatoid arthritis. The hapten carrier model. Arthritis and Rheumatology 2020.72.6:903. DOI: 10.1002/art.41189

Arnoux F, Mariot C, Peen E, Lambert NC, Balandraud N, Roudier J, Auger I. Peptidyl arginine deiminase immunization induces anti-citrullinated protein antibodies in mice with particular MHC types. Proc Natl Acad Sci USA 2017.114(47):E10169. DOI: 10.1073/pnas.1713112114

Arnoux F, Fina F, Lambert N, Balandraud N, Martin M, Ouafik L, Kanaan S, Roudier J, Auger I. New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis. Arthritis and Rheumatology 2016 68:1377. DOI: 10.1002/art.3958

Auger I, Martin M, Balandraud N, Roudier J. RA specific autoantibodies to PAD4 inhibit citrullination of fibrinogen. Arthritis and Rheumatism 2010 62:126. DOI: 10.1002/art.27230

Auger I, Balandraud N, Rak JM, Lambert NC, Martin M, Roudier J. New autoantigens in rheumatoid arthritis: screening 8268 protein arrays with RA patients’ sera. Annals of the Rheumatic Diseases 2009 68:591. DOI: 10.1136/ard.2008.096917

Auger I, Roudier C, Guis S, Balandraud N, Roudier J. HLA-DRB1*0404 is strongly associated with anti-calpastatin antibodies in rheumatoid arthritis. Annals of the Rheumatic Diseases 2007 66(12):1588. DOI: 10.1136/ard.2006.067231

Auger I, Sebbag M, Vincent C, Balandraud N, Guis S, Nogueira L, Svensson B, Cantagrel A, Serre G, Roudier J. Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrin. Arthritis and Rheumatism 2005 11:3424. DOI: 10.1002/art.21391

Auger I, Lepecuchel L, Roudier J. Interaction between HSP73 and HLA-DRB1 alleles associated or not with rheumatoid arthritis. Arthritis and Rheumatism 2002. Apr;46(4):929-33. doi: 10.1002/art.10214.

Auger I, Roudier J. A function for the QKRAA amino acid motif: mediating binding of dnaJ to dnaK. Implications for the association of rheumatoid arthritis with HLA-DR4. Journal of Clinical Investigation 1997 99:1818. DOI: 10.1172/JCI119348

Auger I, Escola JM, Gorvel JP, Roudier J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70 kD heat shock proteins. Nature Medicine 1996 3:306. DOI: 10.1038/nm0396-306