Welcome to the website of the INSERM UMRs 1097 AA
UMRs1097 (Autoimmune Arthritis) analyzes the mechanism of development of inflammatory arthritis defined by three main characteristics the high-risk genetic background, the specific autoantibodies and the predominance in women.
Welcome to the website of the INSERM UMRs 1097 AA
UMRs1097 (Autoimmune Arthritis) analyzes the mechanism of development of inflammatory arthritis defined by three main characteristics the high-risk genetic background, the specific autoantibodies and the predominance in women.
Three main characteristics
UMRs1097 (Autoimmune Arthritis) analyzes the mechanism of development of inflammatory arthritis defined by three main characteristics :
Hight-risk genetic background
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Specific autoantibodies
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Predominance in women
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Discover our world
Our lab
The Research Unit is associated to the rheumatology department at Ste Marguerite hospital and works in collaboration with the French Blood Center and the Beckman Coulter Company. We benefit from the proximity of the Center for ImmunoPHEnomics (CIPHE) dedicated to the construction and phenotyping of mouse models of interest in immunology.
We are studying how the HLA-DRB1 genetic background that predisposes to rheumatoid arthritis (RA) allows anti-citrullinated protein antibodies (ACPA) to develop. ACPAs precede and characterize the disease. We have recently demonstrated in mice that immunization against the enzymes responsible for citrullination, peptidyl arginyl deiminases (PADs), is the event that triggers the appearance of ACPAs. This suggests that prevention of RA in high-risk subjects is possible by anti-PAD tolerization.
Our lab
We also want to understand why women are more often with rheumatic autoimmune diseases (scleroderma, RA). We are particularly interested in cellular transplacental exchanges during pregnancy leading to the presence of maternal cells in children, called maternal microchimerism (Mc) and fetal cells in the mother, called fetal Mc.
We have implemented tools for detecting and quantifying Mc and evaluated Mc presence / frequency in physiological and pathological conditions. We are currently testing its role on the trigger of autoantibody production in a mouse model.
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